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While these trials excluded patients with a formal diagnosis of type 2 diabetes, its highly plausible that a substantial proportion of participants had early metabolic abnormalities, such as insulin resistance , elevated fasting insulin , or even undiagnosed prediabetes

adults with long-standing tendon problems that conventional care has plateaued on

Your body gradually builds up tolerance as your dose increases, which is normal and expectedthis is why dose adjustments typically happen every 4 weeks as your treatment progresses

Mol Hum Reprod 22:1834

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It may also make it harder to maintain long-term weight loss, increasing the risk of rebound weight gain