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In the SURPASS-4 trial, adults with T2DM at heightened cardiovascular risk, who were inadequately managed with oral glucose-lowering agents, once-weekly tirzepatide (5 mg, 10 mg, or 15 mg) were compared to insulin glargine (100 U/mL)

Transl Res (2021) 227:7588

The review cautions that effective dosing, duration, and efficacy for non-metabolic and neuropsychiatric indications, including Alzheimers disease and substance use disorders, remain to be established

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These results show that GLP-1 might act directly through the GPI/IPG-coupled receptor on osteoblastic MC3T3-E1 cells

If youre still falling short of your protein target, talk to your Weight Watchers Clinician or Registered Dietitian about adding a protein supplement