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Both occur naturally in our bodies, and the two interconvert inside the body, and are involved with transporting long-chain fatty-acids into the mitochondria for converting fat into energy via beta oxidation

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However, trials using recombinant IGF peptides or complexes to treat age-related bone disease have been limited by lack of strong anabolic activity, and significant off-target actions such as hypoglycemia and the potential for malignant transformation

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BCL2L13 is a mammalian homolog of the yeast mitophagy receptor Atg32