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If your goal is the gut itself, oral's low systemic bioavailability is largely irrelevant because the action is local

After 5 days, 1.3 and 3.7 log reductions in bacterial viability were recorded when treated with 100 nM and 1.0 M of auranofin, respectively (Harbut et al., 2015)

Wendisch V, Lee J (2020) Metabolic engineering in Corynebacterium glutamicum

Pylori infections damage intestinal structures responsible for B12 absorption

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Aiding Muscle Repair : Growth hormone (HGH) promotes muscle growth and repair by increasing protein synthesis and reducing protein breakdown in muscle cells