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Conclusions A growing body of evidence indicates that several of the pleiotropic responses elicited by GLP-1RAs and SGLT-2is involve the activation of the GH/IGF-1/IGF-1R system

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369,370 Genetic disruption of GLP-1R signaling leads to cortical osteopenia and heightened bone fragility, primarily caused by increased bone resorption by osteoclasts

A patch that delivers only 1030% of the dose needed creates a subtherapeutic effect, leaving patients hungry and without the metabolic benefits of higher doses