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Examples of the non-polar interactions between side chains atoms of GLP-1 and the receptor protein include His7 of GLP-1 forming a hydrogen bond with Gln234 of the receptor

10.3390/ijms26209977 5

The benefit vs

In our study, liraglutide prevented the TGF-1 + IL-1-induced augmentation of mitochondrial respiration in fibroblasts, indicating that activating GLP-1R could maintain mitochondrial homeostasis under inflammatory stress

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