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Additionally, the newly synthesized compounds significantly reduced LPS-induced production of ROS and pro-inflammatory cytokines (IL-6, TNF-, and NO) in RAW 264.7 macrophages

This hypothesized VEGF/VEGFR interaction may activate a complex intracellular signaling cascade, which may involve multiple proteins such as phospholipase C, protein kinase C, and the mitogen-activated protein kinases

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