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Oral semaglutide has a shorter half-life and clears faster, potentially allowing a shorter preoperative pausebut discuss this with your surgical team first

Which of the two forms to use is one of the most-debated questions around this pairing, and the common recommendation No-DAC happens to line up with the pharmacology

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When you inject semaglutide weekly, it slows stomach emptying, increases feelings of fullness, improves blood sugar control, and may reduce food cravings through multiple brain pathways

Many patients report that GLP-1 receptor agonists (e.g., semaglutide) reduce appetite and make food thoughts less intrusive consistent with their known effects on satiety signaling and reward pathways (GLP-1 appetite review

Alternatively, reserving Semax for periods of maximum caloric restriction may provide targeted cognitive support when its most needed