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In trans-Golgi network (TGN), the pro-region is cleaved resulting in the formation of mature BDNF (14 kDa), a biologically active form with C-terminal dimers (10)

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ARPE-19 cells were used for experimentation from passage 3 through 25

doi:10.1016/j.tem.2020.04.003

[Abstract] Compared with guinea pigs receiving periocular injections of vehicle (5 mM, 10 L on days 1, 4, 7, 10, and 13 over two weeks), those treated with glutathione oxidized (Glu, 20 mg/mL, 10 L on the same schedule) exhibited a 1.76-fold increase in relative myopia, along with a 1.78-fold increase in axial length (AL)