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Hypothalamic WNT signalling is impaired during obesity and reinstated by leptin treatment in male mice

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(1) J Ishida, M Saitoh, N Ebner, J Springer, et al (2020) Growth hormone secretagogues: history, mechanism of action, and clinical development JCSM Communications, Volume 3, Issue 1, January/June 2020, Pages 25-37

Others benefit from periodic breaks to maintain effectiveness

This redundancy can be seen in transgenic animals, whereby the genetic absence of a single chemosensor doesn't always result in a phenotype, probably due to metabolic compensation from similar and overlapping pathways