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Regarding the mechanism of action, is the GLP-1RA reducing lymphedema because of the induced weight loss or is there another mechanism at play

Skin thickness, the amount of urushiol absorbed, and proximity to lymphatic drainage all affect when each area reaches peak inflammation

It works by hampering the creation of tyrosine, an amino acid vital for melanin development

Insulin resistance can paradoxically develop during extended cycles as chronic IGF-1 receptor activation triggers compensatory IRS-1 phosphorylation at inhibitory sites this is why insulin sensitizer co-administration becomes more important in cycles longer than 6 weeks

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Cancer , 115 , 741-751, doi: Das, F., Dey, N., Bera, A., Kasinath, B