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It includes consultations with a clinician and a medically appropriate treatment program, which can include medications

[197] demonstrated that polystyrene NPs functionalized by amine groups (PS-NH2) efficiently interact with cell membranes compared to PS-COOH (negatively charged particles)

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Phase 1 is believed to correspond to the high level of activity in the primary afferent as by C-fiber activation due to peripheral stimulation, 9 whereas phase 2 seems to result from the continuous low level of small afferent input, together with a facilitated state of spinal processing

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