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The standard protocol starts at 1mg weekly for 4 weeks, then titrates up monthly: 2mg, 4mg, 8mg, reaching 12mg maintenance

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Accessed 07/03/2015

A central driver of these benefits is vascular repair

Surgical procedures for intraoperative oIGF-1 infusion To test the acute effects of oIGF-1 on anabolic signaling pathways, pregnant Columbia-Rambouillet mixed-breed sheep with ewes carrying either a singleton fetus (n = 1) or twin fetuses (n = 3), underwent maternal laparotomy and hysterotomy under general anesthesia for fetal catheter placement at 136 1 day gestation

Most side effects are gastrointestinal and tend to diminish as the dose is gradually increased