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UK guidance from NICE and the MHRA does not recommend combination weight loss pharmacotherapy

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Given the mix of medications, its difficult to parse out whether the weight loss can be attributed to the combination of phentermine and semaglutide, just one of those medications, or the complete mix of medications and dietary changes

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doi: 10.1016/j.ejphar.2009.12.023 175 McCleanPLParthsarathyVFaivreEHolscherC

Until then, patients should work with their healthcare providers to choose from currently available, proven therapies that can provide meaningful health benefits today